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Mol Brain 17:21

A study in patients with inherited vitamin B12 deficiency

Compared to the placebo, the tripeptide infusion reduced mean daily food intake by 27%, decreased fat intake, increased protein intake, and enhanced satiety, while not altering food preferences and sweet taste function

During PINK1-PARKIN-induced mitophagy, the selective autophagy receptors OPTN and NDP52 redundantly activate TBK1, which in turn phosphorylates the mitophagy receptors OPTN, NDP52 and p62 to ensure their retention at damaged mitochondria and to facilitate the recruitment of ATG8 family proteins (180, 181)